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OALib Journal期刊

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Curcumin: A wonder anticancer drug
Yogesh Panditrao Palve,P.L. Nayak
International Journal of Pharmacy and Biomedical Sciences , 2012,
Abstract: Curcumin [(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5di one] is the major yellow pigment extracted from turmeric, a commonly used spice, derived from the rhizome of the plant Curcuma longa. In India and Southeast Asia, turmeric has long been used as a treatment for inflammation, skin wounds and tumors. Curcumin has broad spectrum cancer chemo preventive activity in preclinical animal models. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulatetranscription factors NF-κB, AP-1 and Egr-1; down-regulate the expression of COX2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1; down-regulate growth factor receptors (such as EGFR and HER2); and inhibit the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. In several systems, curcumin has been described as a potent antioxidant and anti-inflammatory agent. Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis. Pharmacologically, curcumin has been found to be safe. Human clinical trials indicated no dose-limiting toxicity when administered at doses up to 10 g/day. All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting thesestudies.
Pantoea dispersa: Is it the Next Emerging “Monster” in our Intensive Care Units? A Case Report and Review of Literature
Minnu Panditrao,Mridul Panditrao
- , 2018, DOI: 10.4103/aer.AER_147_18
Abstract: Hospital-acquired infections and their consequences are the main cause of morbidity/mortality in critically ill and immunocompromised patients. It becomes interesting when an unusual and uncommon microorganism is found to be the causative agent, rather than the known commensals and opportunists. We present such a case, when a multiparous female, in post lower uterine segment cesarean section period presented with fulminant septic shock, hepatic failure, coagulopathy, and ventilator-associated pneumonitis. The organism grown in the tracheal secretions turned out to be an uncommon, unusual Gram-negative Coccobacillus by the name of Pantoea dispersa, resistant to almost all the conventional antimicrobial agents. In spite of all the efforts, the patient could not be saved. However, the case has opened up a virtual “Pandora's box” of questions. Are these microorganisms, known plant pathogens, really harmful to humans? Are they commensals or virulent opportunists? Are we once again on the way to a new “Acinetobacter,” like near-epidemic? This is an attempt to try and find some insight about this presently uncommon and not well known genus of Pantoea! We have tried to trace and review the related available literature in the clinical medicine
Can repeated scorpion bite lead to development of resistance to the effect of local anesthetics? Maybe it does!  [PDF]
Mridul M. Panditrao, Minnu M. Panditrao, V. Sunilkumar, Aditi M. Panditrao
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.22049
Abstract:

An 80 years old, bronchial asthmatic, male was posted for left cataract extraction with intra ocular lens implantation. He was administered peribulbar block/left facial nerve block. There was no sensory or motor block. Thereafter peribulbar block was repeated. Only partial akinesia was achieved, so under intermittent intra venous sedation, the surgery continued for 40 minutes. In the post-operative period, no signs of any residual/delayed block were noted. On specific enquiry, patient gave history of scorpion bite thrice, at the age of 27 years on his right foot, about 8-9 years back and again about 6-7 months back on his right hand. On 4th post-operative day after obtaining informed consent, local infiltration of the skin on the ventral aspect of the forearm, using, 6 mL, 2% lignocaine with adrenaline, was carried out. Confirming the suspicion, there was no sensory block after the injection, confirmed by pin prick method. Peribulbar block produces adequate intra-operative analgesia for cataract extraction. The cause of the failures may be due to technical inability to achieve block. However failure that occurs despite of technically correct injection of the correct drug can be mystifying. As the scorpion venom is known to affect the pumping mechanism of sodium channels in the nerve fibres, which are involved in the mechanism of action of local anaesthetic drugs, it may be responsible for the development of “resistance” to the action of local anaesthetic agents.

An unanticipated cardiac arrest and unusual post-resuscitation psycho-behavioural phenomena/near death experience in a patient with pregnancy induced hypertension and twin pregnancy undergoing elective lower segment caesarean section
Panditrao Mridul,Singh Chanchal,Panditrao Minnu
Indian Journal of Anaesthesia , 2010,
Abstract: A case report of a primigravida, who was admitted with severe pregnancy induced hypertension (BP 160/122 mmHg) and twin pregnancy, is presented here. Antihypertensive therapy was initiated. Elective LSCS under general anaesthesia was planned. After the birth of both the babies, intramyometrial injections of Carboprost and Pitocin were administered. Immediately, she suffered cardiac arrest. Cardio pulmonary resucitation (CPR) was started and within 3 minutes, she was successfully resuscitated. The patient initially showed peculiar psychological changes and with passage of time, certain psycho-behavioural patterns emerged which could be attributed to near death experiences, as described in this case report.
Study of Wrist Ratio and Wrist-to-Palm Index Radio in Individuals Suffering from Carpal Tunnel Syndrome
Sachin Bhaskar Palve,Suchitra Sachin Palve
- , 2019, DOI: 10.4103/aian.AIAN_343_18
Abstract: Carpal tunnel syndrome (CTS) is the commonest median nerve entrapment neuropathy, with preponderance in females
Clinico-pathological correlation of micronuclei in oral squamous cell carcinoma by exfoliative cytology
Palve Devendra,Tupkari Jagdish
Journal of Oral and Maxillofacial Pathology , 2008,
Abstract: Oral squamous cell carcinoma accounts for 90% to 95% of all oral malignancies. Though its diagnosis seldom presents difficulty, it is the cancer staging and histopathological grading that are important to prognostication; and micronuclei are good prognostic indicators. Micronucleus frequencies in oral exfoliated cells stained with papanicolaou stain were counted and correlated with the histopathological grades and clinical stages of squamous cell carcinoma patients. They were also compared with healthy control subjects. Micronuclei (MN) frequencies were found higher in squamous cell carcinoma patients than in control subjects. MN frequencies were also found to be raised with increasing histological grades of squamous cell carcinoma.
Validation of High-Density Airborne LiDAR-Based Feature Extraction Using Very High Resolution Optical Remote Sensing Data  [PDF]
Shridhar D. Jawak, Satej N. Panditrao, Alvarinho J. Luis
Advances in Remote Sensing (ARS) , 2013, DOI: 10.4236/ars.2013.24033
Abstract:

This work uses the canopy height model (CHM) based workflow for individual tree crown delineation from LiDAR point cloud data in an urban environment and evaluates its accuracy by using very high-resolution PAN (spatial) and 8-band WorldView-2 imagery. LiDAR point cloud data were used to detect tree features by classifying point elevation values. The workflow includes resampling of LiDAR point cloud to generate a raster surface or digital terrain model, generation of hill-shade image and intensity image, extraction of digital surface model, generation of bare earth digital elevation model and extraction of tree features. Scene dependent extraction criteria were employed to improve the tree feature extraction. LiDAR-based refining/filtering techniques used for bare earth layer extraction were crucial for improving the subsequent tree feature extraction. The PAN-sharpened WV-2 image (with 0.5 m spatial resolution) used to assess the accuracy of LiDAR-based tree features provided an accuracy of 98%. Based on these inferences, we conclude that the LiDAR-based tree feature extraction is a potential application which can be used for understanding vegetation characterization in urban setup.

A prospective study to compare the incidence of post-operative nausea, vomiting (PONV) in female patients undergoing surgical procedures under general anaesthesia during proliferative and secretory phase of menstrual cycle
Aditi M Panditrao,Minnu M Panditrao,Mridul M Panditrao,Imran Azher
International Journal of Students' Research , 2011, DOI: 10.5549/ijsr.1.2.51-56
Abstract: Introduction: As the female hormones are emetogenic in nature, females in their reproductive period are more predisposed to Nausea/Vomiting in the non-pregnant, pregnant state as well as in the post operative period. This study was conducted to find the influence of the phase of the menstrual cycle on PONV, the alertness and pain perception, after general anaesthesia, in the postoperative period. Methodology: After obtaining the approval of IEC, the study was conducted on 60 young, healthy and consenting female patients. As per the date of their last menstrual cycle patients were divided into two groups: Group A: Patients in proliferative phase (1 to 14th day); Group B: Patients in luteal phase (15 to 30th day). All the patients had standardized method of general anaesthesia. The assessment of the patients for nausea, vomiting, pain and sedation was carried out using specific scoring systems & visual analogue score (VAS) at 30 min, 60 min, 90min, 2 hrs, 6hrs, 12hrs and 24 hrs post operatively by a blinded impartial observer. Patients were given rescue antiemetic and NSAID, as and when required. Results: 26 patients were allocated to group A and 36 to group B. No statistically significant difference was found, in demographic profile, vital parameters, sedation score, VAS (pain score) and the duration of surgery. Although Group A patients had higher nausea/ vomiting score than the group B patients, throughout the post-operative period, the difference was highly significant at 90 min and 12 hours postoperatively. The percentage of patients, having PONV (reflecting incidence), in group A was significantly higher (76.8%) than in group B (32.35%). Conclusion: [The incidence and severity of nausea vomiting in the post operative period is definitely influenced/increased by the Proliferative phase of the menstrual cycle.
Cosmic String in Bianchi Type-III Space-Time with Bulk Viscosity and Magnetic Field  [PDF]
Sharad Panditrao Kandalkar, Amrapali Pandurang Wasnik, Sunita Padmakar Gawande, Mohini Nilkanth Gaikwad
International Journal of Astronomy and Astrophysics (IJAA) , 2012, DOI: 10.4236/ijaa.2012.24029
Abstract: We investigate some locally rotationally symmetric (LRS) Bianchi type-III string cosmological model in the presence of bulk viscosity and magnetic field, where an equation of state \"\" and relation between metric potential \"\" are considered. The solution describes a shearing and non-rotating model with big-bang start. In the absence of magnetic field it reduces to a string model with bulk viscosity, where the relation between the coefficient of bulk viscosity and the energy density is \"\" for a = 0.
Integration of Quality Function Deployment and Value Engineering in Furniture Manufacturing Industry for Improvement of Computer Work Station
Chougule Mahadeo Annappa,,Kallurkar Shrikant Panditrao
International Journal of Innovative Technology and Exploring Engineering , 2013,
Abstract: Manufacturing operations in the Indian furniture industry are currently very competitive. It is necessary for entrepreneurs to improve the quality of their products and to develop processes including quality management to obtain new product design and development. Quality function deployment technique can be used in the processing development of new Computer work station to improve customer satisfaction. The use of QFD would enlarge the chance of success, produce higher quality products, and decrease the cost. The Computer Work Station was selected for this research because of its high sales number and it is most complicated compared to other furniture products. The ultimate goal of this research is to design and produce a new type of Computer Work Station. Important ratings of customer requirements are increased to some extent by effective implementation of Value Engineering with QFD. The result revealed that the average satisfaction values for all new types of computer work station are increased over those of the current computer work station from 1131 to 1956 (54.45%). Also design target values are increased from 1138 to 1988 (79.14%). Therefore with QFD approach, there is significant increase in average customer satisfaction between the current and the new designs.
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